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Health, Agri-food and Bioeconomy






M€ budget



The objective of the project is to explore and consolidate a technology capable of endowing the capabilities of extracellular vesicles (EVs) to superparamagnetic nanodevices by “dressing” them with a “suit” of one or more layers of EV membrane “fabric.”


Until a few years ago, cell communication was thought to be regulated exclusively through cell-cell junctions or by the exchange of soluble molecular factors. However, it has been discovered that membranous nanoparticles, called extracellular nanovesicles (EVs), and tunneling nanotubes are also intercellular communication agents “made by cells for cells.” Their function is to transport lipids, proteins and nucleic acids, and they stand out for their precision and targeting ability, carried out thanks to the unique composition and structure of their membrane (which to date is inaccessible to synthetic mimics).


The BOW project will develop a technology capable of endowing the capabilities of extracellular vesicles (EVs) to superparamagnetic nanodevices (Magnetic Bead Devices, MBDs) by “dressing” them with a “suit” of one or several layers of EV membrane “fabric.” It will establish a general and viable paradigm for applying key biomimetic functions – including the ability to evade the immune system and reach target organs/tissues/tumors – to any synthetic nanodevice. In turn, it will be disruptive in that it will be the first example of biogenic nanotechnology.


This technology will promote the progress of implantable nanodevices and nanomaterials towards sustainable production and the clinic, impacting people’s quality of life. The main objectives include: i) production of EVs with biomimetic and organotropic functions, ii) synthesis and functionalisation of MBDs, iii) engineering of a microfluidic device for optimised fabrication of membrane-coated MBD EVs, iv) evaluation of biological performance and nanotoxicity of evMBDs and in-vitro, ex-vivo and in-vivo.

This project has received funding from the European Union’s FET Proactive programme, under grant agreement No. 952183.

Arántzazu Albístur

“The BOW project will develop and demonstrate an innovative technology based on extracellular vesicles and paragenetic nanodevices with applications in various fields related to human health (clinical, environmental and food safety). BOW is a clear example of science at the service of society.”

Aránzazu Albístur

Kaila platform Manager

Team involved


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